Rare Target Detection Overview

Circulating tumor cells (CTC) can be present in whole blood at concentrations at or below 1 in 10⁹ peripheral blood cells (PBC). EpiSep XRC™ is a patented method that allows for direct recovery and detection of CTC at low levels using Xenographic Retention Chromatography. EpiSep XRC™ Tumor Cell Recovery kits provide the simplest and most advanced method for detection and quantitation of circulating tumor cells.

Example – EpiSep XRC™, How It Works

Specimen and reagents are added directly to the EpiSep XRC™
Slide. There are no transfer steps that can lose rare cells.

Reagents that allow CTC to be identified by morphology, nucleation,
and cytokeratin 8/18 immunofluorescence are included with the EpiSep XRC™
EpCAM Tumor Cell Recovery kit. Once reagent addition is complete
no magnetic field is necessary and EpiSep can be viewed, handled and stored
in the same manner as other conventional immunofluorescent slide preparations.

Ref. 060303-139a